2021 Rafa Nadal Open

Country	Player	Rank1	Seed
JPN	Yasutaka Uchiyama	123	1
ESP	Fernando Verdasco	132	2
GBR	Liam Broady	147	3
POR	João Sousa	149	4
AUT	Sebastian Ofner	166	5
CHI	Marcelo Tomás Barrios Vera	172	6
POL	Kacper Żuk	173	7
SLO	Blaž Rola	179	8

• ¹ Rankings are as of 23 August 2021.^[1]

The following players received wildcards into the singles main draw:

• Nicolás Álvarez Varona
• Carlos Gómez-Herrera
• Daniel Rincón

The following players received entry into the singles main draw as alternates:

• Evgeny Karlovskiy
• Stefan Kozlov
• Nicolás Mejía
• Hiroki Moriya
• Roberto Ortega Olmedo
• Roberto Quiroz

The following players received entry from the qualifying draw:

• Nick Chappell
• Michael Geerts
• Alejandro González
• Johannes Härteis

The following players received entry as lucky losers:

• Nicolas Moreno de Alboran
• Jan Zieliński

• Lukáš Lacko def. Yasutaka Uchiyama 5–7, 7–6^(10–8), 6–1.

• Karol Drzewiecki / Sergio Martos Gornés def. Fernando Romboli / Jan Zieliński 6–4, 4–6, [10–3].