2021 Tenerife Challenger

Country	Player	Rank1	Seed
NED	Tallon Griekspoor	89	1
ESP	Feliciano López	109	2
ESP	Fernando Verdasco	144	3
FRA	Quentin Halys	148	4
ECU	Emilio Gómez	149	5
TUR	Altuğ Çelikbilek	164	6
SWE	Elias Ymer	168	7
POR	João Sousa	173	8

• ¹ Rankings are as of 25 October 2021.^[1]

The following players received wildcards into the singles main draw:

• Feliciano López
• Daniel Rincón
• Fernando Verdasco

The following player received entry into the singles main draw using a protected ranking:

• Joris De Loore

The following players received entry from the qualifying draw:

• Yan Bondarevskiy
• David Ionel
• Vladyslav Orlov
• Alexander Shevchenko

The following player received entry as a lucky loser:

• Filip Jianu

• Tallon Griekspoor def. Feliciano López 6–4, 6–4.

• Nuno Borges / Francisco Cabral def. Jeevan Nedunchezhiyan / Purav Raja 6–3, 6–4.