2021 Open de Tenis Ciudad de Pozoblanco

Country	Player	Rank1	Seed
FRA	Benjamin Bonzi	108	1
FRA	Grégoire Barrère	137	2
TUR	Altuğ Çelikbilek	199	3
TUR	Cem İlkel	204	4
FRA	Maxime Janvier	229	5
CRO	Borna Gojo	235	6
GER	Yannick Maden	241	7
ESP	Nicola Kuhn	250	8

• ¹ Rankings are as of July 12, 2021.^[1]

The following players received wildcards into the singles main draw:

• Nicolás Álvarez Varona
• Alberto Barroso Campos
• Blas Ruiz Romero

The following players received entry into the singles main draw as alternates:

• Carlos Gómez-Herrera
• Skander Mansouri
• Rayane Roumane

The following players received entry from the qualifying draw:

• Mathias Bourgue
• Michael Geerts
• Matteo Martineau
• Emilio Nava

The following player received entry as a lucky loser:

• Federico Zeballos

• Altuğ Çelikbilek def. Cem İlkel 6–1, 6–7^(2–7), 6–3.

• Igor Sijsling / Tim van Rijthoven def. Diego Hidalgo / Sergio Martos Gornés 5–7, 7–6^(7–4), [10–5].