2021 Las Vegas Challenger

Country	Player	Rank1	Seed
USA	Steve Johnson	88	1
USA	Denis Kudla	91	2
USA	Tennys Sandgren	96	3
GER	Daniel Altmaier	110	4
JPN	Taro Daniel	121	5
USA	Mitchell Krueger	148	6
ECU	Emilio Gómez	151	7
TPE	Jason Jung	161	8

• ¹ Rankings are as of October 18, 2021.^[1]

The following players received wildcards into the singles main draw:

• Christopher Bulus
• Aleksandar Kovacevic
• Jordan Sauer

The following player received entry into the singles main draw as an alternate:

• Stefan Kozlov

The following players received entry from the qualifying draw:

• Dayne Kelly
• Shintaro Mochizuki
• Mukund Sasikumar
• Donald Young

The following players received entry as lucky losers:

• Nick Chappell
• Aidan McHugh

• J. J. Wolf def. Stefan Kozlov 6–4, 6–4.

• William Blumberg / Max Schnur def. Jason Jung / Evan King 7–5, 6–7^(5–7), [10–5].