2021 Garden Open

Country	Player	Rank1	Seed
FRA	Grégoire Barrère	116	1
BOL	Hugo Dellien	122	2
ITA	Paolo Lorenzi	154	3
AUT	Sebastian Ofner	159	4
FRA	Hugo Gaston	160	5
PER	Juan Pablo Varillas	161	6
ITA	Lorenzo Giustino	168	7
CAN	Steven Diez	176	8

• ¹ Rankings as of 12 April 2021.^[1]

The following players received wildcards into the singles main draw:

• Stefano Napolitano
• Andrea Pellegrino
• Giulio Zeppieri

The following player received entry into the singles main draw using a protected ranking:

• Thanasi Kokkinakis

The following player received entry into the singles main draw as a special exempt:

• Mathias Bourgue

The following players received entry into the singles main draw as alternates:

• Andrea Collarini
• Borna Gojo

The following players received entry from the qualifying draw:

• Flavio Cobolli
• Vít Kopřiva
• Tristan Lamasine
• Alex Molčan

• Andrea Pellegrino def. Hugo Gaston 3–6, 6–2, 6–1.

• Sadio Doumbia / Fabien Reboul def. Paolo Lorenzi / Juan Pablo Varillas 7–6^(7–5), 7–5.