2021 Internationaux de Tennis de Vendée

Country	Player	Rank1	Seed
FRA	Benjamin Bonzi	64	1
CZE	Jiří Veselý	86	2
GER	Peter Gojowczyk	87	3
ITA	Andreas Seppi	95	4
FRA	Gilles Simon	99	5
FRA	Pierre-Hugues Herbert	100	6
LTU	Ričardas Berankis	106	7
SVK	Norbert Gombos	114	8

• ¹ Rankings are as of 27 September 2021.^[1]

The following players received wildcards into the singles main draw:

• Arthur Fils
• Kyrian Jacquet
• Harold Mayot

The following player received entry into the singles main draw as an alternate:

• Constant Lestienne

The following players received entry from the qualifying draw:

• Zizou Bergs
• Titouan Droguet
• Evgeny Karlovskiy
• Mats Rosenkranz

The following player received entry as a lucky loser:

• Kenny de Schepper

• Jiří Veselý def. Norbert Gombos 6–4, 6–4.

• Jonathan Eysseric / Quentin Halys def. David Pel / Aisam-ul-Haq Qureshi 4–6, 7–6^(7–5), [10–8].