2021 Open Bogotá

Country	Player	Rank1	Seed
COL	Daniel Elahi Galán	105	1
GER	Daniel Altmaier	114	2
CZE	Vít Kopřiva	198	3
CHI	Nicolás Jarry	217	4
ARG	Facundo Mena	245	5
NED	Jesper de Jong	246	6
USA	Ulises Blanch	256	7
TUN	Malek Jaziri	287	8

• ¹ Rankings are as of 4 October 2021.^[2]

The following players received wildcards into the singles main draw:

• Alejandro Gómez
• Juan Sebastián Gómez
• Enrique Peña

The following player received entry into the singles main draw using a protected ranking:

• Gerald Melzer

The following player received entry into the singles main draw as an alternate:

• Matías Zukas

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Luca Castelnuovo
• Enzo Couacaud
• Jaroslav Pospíšil

• Gerald Melzer def. Facundo Mena 6–2, 3–6, 7–6^(7–5).

• Nicolás Jarry / Roberto Quiroz def. Nicolás Barrientos / Alejandro Gómez 6–7^(4–7), 7–5, [10–4].