2021 Tennis Napoli Cup

Country	Player	Rank1	Seed
ITA	Stefano Travaglia	97	1
SVK	Andrej Martin	122	2
GER	Yannick Hanfmann	123	3
NED	Tallon Griekspoor	131	4
CZE	Zdeněk Kolář	148	5
ITA	Alessandro Giannessi	181	6
ITA	Gian Marco Moroni	205	7
ITA	Lorenzo Giustino	213	8

• ¹ Rankings as of 27 September 2021.^[1]

The following players received wildcards into the singles main draw:

• Matteo Arnaldi
• Jacopo Berrettini
• Luca Nardi

The following player received entry into the singles main draw using a protected ranking:

• Filippo Baldi

The following player received entry into the singles main draw as an alternate:

• Miljan Zekić

The following players received entry from the qualifying draw:

• Bogdan Ionuț Apostol
• Raúl Brancaccio
• Marco Miceli
• Julian Ocleppo

The following players received entry as lucky losers:

• Alexandru Jecan
• Petros Tsitsipas

• Tallon Griekspoor def. Andrea Pellegrino 6–3, 6–2.

• Dustin Brown / Andrea Vavassori def. Mirza Bašić / Nino Serdarušić 7–5, 7–6^(7–5).