2021 Split Open II

Country	Player	Rank1	Seed
FRA	Grégoire Barrère	116	1
AUS	Marc Polmans	149	2
FRA	Hugo Gaston	158	3
EGY	Mohamed Safwat	160	4
BEL	Kimmer Coppejans	168	5
ITA	Lorenzo Giustino	169	6
SVK	Filip Horanský	175	7
CAN	Steven Diez	177	8

• Rankings are as of 5 April 2021.^[1]

The following players received wildcards into the singles main draw:

• Duje Ajduković
• Duje Kekez
• Nino Serdarušić

The following players received entry into the singles main draw using protected rankings:

• Dustin Brown
• Thanasi Kokkinakis

The following players received entry into the singles main draw as special exempts:

• Pedro Cachin
• Blaž Kavčič

The following players received entry from the qualifying draw:

• Mirza Bašić
• Lukáš Klein
• Zdeněk Kolář
• Kacper Żuk

The following player received entry as a lucky loser:

• Andrea Collarini

• Kacper Żuk def. Mathias Bourgue 6–4, 6–2.

• Szymon Walków / Jan Zieliński def. Grégoire Barrère / Albano Olivetti 6–2, 7–5.