2021 Open Città della Disfida
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| 2021 Open Città della Disfida | |
|---|---|
| Date | 23–29 August |
| Edition | 21st |
| Surface | Clay |
| Location | Barletta, Italy |
| Champions | |
| Singles | |
 Giulio Zeppieri | |
| Doubles | |
Marco Bortolotti /  Cristian Rodríguez | |
The 2021 Open Città della Disfida was a professional tennis tournament played on clay courts. It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Barletta, Italy between 23 and 29 August 2021.
Due to COVID-19 pandemic, the 2020 edition of the tournament was not held and the 2021 edition was rescheduled from the traditional dates in April.
