2021 Open Sopra Steria de Lyon

Country	Player	Rank1	Seed
URU	Pablo Cuevas	92	1
ESP	Fernando Verdasco	99	2
ARG	Facundo Bagnis	104	3
COL	Daniel Elahi Galán	107	4
JPN	Taro Daniel	113	5
FRA	Benjamin Bonzi	116	6
ARG	Francisco Cerúndolo	117	7
GER	Cedrik-Marcel Stebe	135	8

• ¹ Rankings are as of 31 May 2021.^[1]

The following players received wildcards into the singles main draw:

• Titouan Droguet
• Kyrian Jacquet
• Matteo Martineau

The following player received entry into the singles main draw as a special exempt:

• Holger Rune

The following players received entry from the qualifying draw:

• Pedro Cachin
• Manuel Guinard
• Camilo Ugo Carabelli
• Alexey Vatutin

The following players received entry as lucky losers:

• Michael Geerts
• Laurent Lokoli

• Pablo Cuevas def. Elias Ymer 6–2, 6–2.

• Martín Cuevas / Pablo Cuevas def. Tristan Lamasine / Albano Olivetti 6–3, 7–6^(7–2).