2021 Internazionali di Tennis Città di Verona

Country	Player	Rank1	Seed
ESP	Carlos Taberner	106	1
KAZ	Dmitry Popko	181	2
ITA	Paolo Lorenzi	189	3
DEN	Holger Rune	191	4
GBR	Jay Clarke	219	5
FRA	Maxime Janvier	235	6
ITA	Lorenzo Giustino	236	7
POR	Gastão Elias	239	8

• ¹ Rankings as of 9 August 2021.^[1]

The following players received wildcards into the singles main draw:

• Marco Bortolotti
• Fletcher Scott
• Giulio Zeppieri

The following player received entry into the singles main draw as a special exempt:

• Orlando Luz

The following player received entry into the singles main draw as an alternate:

• Filippo Baldi

The following players received entry from the qualifying draw:

• Nerman Fatić
• Francesco Forti
• Matija Pecotić
• Matheus Pucinelli de Almeida

• Holger Rune def. Nino Serdarušić 6–4, 6–2.

• Sadio Doumbia / Fabien Reboul def. Luca Margaroli / Gonçalo Oliveira 7–5, 4–6, [10–6].