2021 Vesuvio Cup

Country	Player	Rank1	Seed
ARG	Federico Coria	67	1
ITA	Marco Cecchinato	82	2
FRA	Hugo Gaston	112	3
SVK	Alex Molčan	117	4
NED	Tallon Griekspoor	118	5
SVK	Andrej Martin	120	6
ESP	Bernabé Zapata Miralles	122	7
GER	Yannick Hanfmann	125	8

• ¹ Rankings are as of 4 October 2021.^[1]

The following players received wildcards into the singles main draw:

• Matteo Arnaldi
• Jacopo Berrettini
• Raúl Brancaccio

The following player received entry into the singles main draw using a protected ranking:

• Filippo Baldi

The following player received entry into the singles main draw as an alternate:

• Andrea Arnaboldi

The following players received entry from the qualifying draw:

• Luciano Darderi
• Jonáš Forejtek
• Álvaro López San Martín
• Alexander Ritschard

The following player received entry as a lucky loser:

• Evan Furness

• Tallon Griekspoor def. Alexander Ritschard 6–3, 6–2.

• Marco Bortolotti / Sergio Martos Gornés def. Dustin Brown / Andrea Vavassori 6–4, 3–6, [10–7].