2021 Internazionali di Tennis del Friuli Venezia Giulia

Country	Player	Rank1	Seed
ITA	Stefano Travaglia	88	1
FRA	Gilles Simon	102	2
ARG	Francisco Cerúndolo	118	3
PER	Juan Pablo Varillas	125	4
BOL	Hugo Dellien	140	5
FRA	Antoine Hoang	145	6
ARG	Juan Manuel Cerúndolo	146	7
ITA	Federico Gaio	149	8

• ¹ Rankings are as of 26 July 2021.^[1]

The following players received wildcards into the singles main draw:

• Filippo Baldi
• Riccardo Bonadio
• Luca Nardi

The following player received entry into the singles main draw as a special exempt:

• Thiago Agustín Tirante

The following player received entry into the singles main draw as an alternate:

• Pavel Kotov

The following players received entry from the qualifying draw:

• Francesco Forti
• Alejandro González
• Camilo Ugo Carabelli
• Giulio Zeppieri

• Francisco Cerúndolo def. Tomás Martín Etcheverry 6–1, 6–2.

• Orlando Luz / Rafael Matos def. Sergio Galdós / Renzo Olivo 6–4, 7–6^(7–5).