2021 Open du Pays d'Aix

Country	Player	Rank1	Seed
ESP	Roberto Carballés Baena	95	1
ESP	Fernando Verdasco	99	2
ARG	Facundo Bagnis	104	3
ARG	Francisco Cerúndolo	117	4
PER	Juan Pablo Varillas	130	5
ESP	Carlos Taberner	137	6
FRA	Hugo Gaston	141	7
IND	Sumit Nagal	143	8

• ¹ Rankings as of 31 May 2021.^[1]

The following players received wildcards into the singles main draw:

• Arthur Cazaux
• Kyrian Jacquet
• Matteo Martineau

The following players received entry into the singles main draw as alternates:

• Javier Barranco Cosano
• Geoffrey Blancaneaux
• Agustín Velotti

The following players received entry from the qualifying draw:

• Aziz Dougaz
• Titouan Droguet
• Oriol Roca Batalla
• Nikolás Sánchez Izquierdo

The following player received entry as a lucky loser:

• Oscar José Gutierrez

• Carlos Taberner def. Manuel Guinard 6–2, 6–2.

• Sadio Doumbia / Fabien Reboul def. Robert Galloway / Alex Lawson 6–7^(4–7), 7–5, [10–4].