2022 Internationaux de Tennis de Vendée

Country	Player	Rank1	Seed
CZE	Jiří Lehečka	74	1
USA	J. J. Wolf	75	2
FRA	Hugo Gaston	81	3
FRA	Richard Gasquet	83	4
FRA	Quentin Halys	84	5
FRA	Hugo Grenier	97	6
SVK	Norbert Gombos	98	7
CZE	Tomáš Macháč	107	8

• ¹ Rankings are as of 26 September 2022.^[1]

The following players received wildcards into the singles main draw:

• Arthur Fils
• Vasek Pospisil
• Clément Tabur

The following players received entry into the singles main draw as alternates:

• Arthur Cazaux
• Vitaliy Sachko

The following players received entry from the qualifying draw:

• Mathias Bourgue
• Jurgen Briand
• Alexis Gautier
• Jules Marie
• David Poljak
• Valentin Royer

The following player received entry as a lucky loser:

• Kenny de Schepper

• Jelle Sels def. Vasek Pospisil 6–4, 6–3.

• Sander Arends / David Pel def. Purav Raja / Divij Sharan 6–7^(1–7), 7–6^(8–6), [10–6].