2022 Las Vegas Challenger

Country	Player	Rank1	Seed
USA	Denis Kudla	99	1
USA	Steve Johnson	117	2
CAN	Vasek Pospisil	121	3
USA	Stefan Kozlov	133	4
ARG	Juan Pablo Ficovich	143	5
USA	Ben Shelton	159	6
ARG	Facundo Mena	161	7
USA	Aleksandar Kovacevic	165	8

• ¹ Rankings are as of October 17, 2022.^[1]

The following players received wildcards into the singles main draw:

• Alexander Cozbinov
• Cannon Kingsley
• Maxim Verboven

The following player received entry into the singles main draw as an alternate:

• Govind Nanda

The following players received entry from the qualifying draw:

• Simon Carr
• Omni Kumar
• Aidan Mayo
• Alfredo Perez
• Jack Pinnington Jones
• Tennys Sandgren

• Tennys Sandgren def. Stefan Kozlov 7–5, 6–3.

• Julian Cash / Henry Patten def. Constantin Frantzen / Reese Stalder 6–4, 7–6^(7–1).