2022 Open Sopra Steria de Lyon

Country	Player	Rank1	Seed
ARG	Federico Coria	54	1
FRA	Richard Gasquet	70	2
BOL	Hugo Dellien	90	3
ESP	Pablo Andújar	98	4
POR	Nuno Borges	134	5
CHI	Tomás Barrios Vera	137	6
FRA	Corentin Moutet	138	7
FRA	Manuel Guinard	145	8

• ¹ Rankings are as of 23 May 2022.^[1]

The following players received wildcards into the singles main draw:

• Ugo Blanchet
• Kyrian Jacquet
• Luca Van Assche

The following player received entry into the singles main draw as a special exempt:

• Tomás Barrios Vera

The following players received entry from the qualifying draw:

• Kimmer Coppejans
• Gabriel Décamps
• Arthur Fils
• Ivan Gakhov
• Shang Juncheng
• Alexey Vatutin

The following players received entry as lucky losers:

• Maxime Janvier
• Juan Bautista Torres

• Corentin Moutet def. Pedro Cachin 6–4, 6–4.

• Romain Arneodo / Jonathan Eysseric def. Sander Arends / David Pel 7–5, 4–6, [10–4].