RTI-120

RTI-120 ((–)-2β-carbophenoxy-3β-(p-tolyl)tropane or RTI-4229-120) is a phenyltropane derivative which acts as a reasonably selective dopamine reuptake inhibitor, along with weaker inhibition of noradrenaline and serotonin reuptake.^[1] It has a reasonably fast rate of occupancy of dopamine transporters in the brain, though slower than that of cocaine itself.^[2] RTI-120 has a short duration of action, along with other p-methyl substituted phenyltropanes such as RTI-150, RTI-171 and RTI-199, giving it a more similar pharmacological profile to cocaine compared to longer acting analogues like RTI-121 and RTI-177.^[3]

CAS Number

• 146145-20-2

PubChem CID

• 10109793

ChemSpider

• 34948082

UNII

• 532Y5K4NMA

Quick facts Identifiers, CAS Number ...

RTI-120

Identifiers
IUPAC name Phenyl (1R,2S,3S,5S)-3-(4-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
CAS Number	146145-20-2
PubChem CID	10109793
ChemSpider	34948082
UNII	532Y5K4NMA
CompTox Dashboard (EPA)	DTXSID80569584
Chemical and physical data
Formula	C22H25NO2
Molar mass	335.447 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1[C@@H]2C[C@H](C3=CC=C(C)C=C3)[C@H](C(OC4=CC=CC=C4)=O)[C@H]1CC2
InChI InChI=1S/C22H25NO2/c1-15-8-10-16(11-9-15)19-14-17-12-13-20(23(17)2)21(19)22(24)25-18-6-4-3-5-7-18/h3-11,17,19-21H,12-14H2,1-2H3/t17-,19+,20+,21-/m0/s1 Key:HIQHQNWJRSNELD-KCLUMXDGSA-N
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