5-I-R91150

5-I-R91150
Identifiers
	IUPAC name 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide;
CAS Number	155928-24-8 ;
PubChem CID	132997;
ChemSpider	117371 ;
UNII	T0W602CN0W;
CompTox Dashboard (EPA)	DTXSID90165995 ;
Chemical and physical data
Formula	C23H29FIN3O2
Molar mass	525.407 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Ic1cc(c(OC)cc1N)C(=O)NC3(CCN(CCCc2ccc(F)cc2)CC3)C;
	InChI InChI=1S/C23H29FIN3O2/c1-23(27-22(29)18-14-19(25)20(26)15-21(18)30-2)9-12-28(13-10-23)11-3-4-16-5-7-17(24)8-6-16/h5-8,14-15H,3-4,9-13,26H2,1-2H3,(H,27,29) ; Key:MIPHZURHMMOGLS-UHFFFAOYSA-N ;
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5-I-R91150 (or R93274) is a compound that acts as a potent and selective antagonist of 5-HT_2A receptors.^[1] Its main application is as its iodine-123 radiolabeled form, in which it can be used in SPECT scanning^[2] in human neuroimaging studies, to examine the distribution of the 5-HT_2A receptor subtype in the brain, e.g. with respect to sex and age^[3] and in adults with Asperger syndrome^[4] or Alzheimer's disease.^[5]

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An alternative 5-HT_2A receptor ligand also used in neuroimaging is altanserin.

References

Identifiers

IUPAC name 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide
CAS Number	155928-24-8^N
PubChem CID	132997
ChemSpider	117371^Y
UNII	T0W602CN0W
CompTox Dashboard (EPA)	DTXSID90165995
Chemical and physical data
Formula	C₂₃H₂₉FIN₃O₂
Molar mass	525.407 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Ic1cc(c(OC)cc1N)C(=O)NC3(CCN(CCCc2ccc(F)cc2)CC3)C
InChI InChI=1S/C23H29FIN3O2/c1-23(27-22(29)18-14-19(25)20(26)15-21(18)30-2)9-12-28(13-10-23)11-3-4-16-5-7-17(24)8-6-16/h5-8,14-15H,3-4,9-13,26H2,1-2H3,(H,27,29)^Y Key:MIPHZURHMMOGLS-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)