YM-348

YM-348
Identifiers
	IUPAC name (2S)-1-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)propan-2-amine;
CAS Number	372163-84-3;
PubChem CID	3045225;
IUPHAR/BPS	230;
ChemSpider	2308001;
UNII	VTV38S7D39;
CompTox Dashboard (EPA)	DTXSID50190708 ;
Chemical and physical data
Formula	C14H17N3O
Molar mass	243.310 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC;
	InChI InChI=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14(10)12)8-9(2)15/h4-7,9H,3,8,15H2,1-2H3/t9-/m0/s1; Key:QLOOWOVVZLBYHU-VIFPVBQESA-N;
	(verify)

YM-348 is an indazolethylamine derivative drug which acts as a potent and selective 5-HT_2C receptor agonist, with an EC₅₀ of 1nM and 15x selectivity over 5-HT_2A, although it only has moderate selectivity of 3x over the closely related 5-HT_2B receptor.^[1]^[2] It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.^[3]^[4]^[5]^[6]

CAS Number

372163-84-3

PubChem CID

3045225

IUPHAR/BPS

230

ChemSpider

2308001

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YM-348

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Identifiers


IUPAC name (2S)-1-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)propan-2-amine
CAS Number	372163-84-3
PubChem CID	3045225
IUPHAR/BPS	230
ChemSpider	2308001
UNII	VTV38S7D39
CompTox Dashboard (EPA)	DTXSID50190708
Chemical and physical data
Formula	C₁₄H₁₇N₃O
Molar mass	243.310 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC
InChI InChI=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14(10)12)8-9(2)15/h4-7,9H,3,8,15H2,1-2H3/t9-/m0/s1 Key:QLOOWOVVZLBYHU-VIFPVBQESA-N
(verify)