LY-456220

LY-456220
Identifiers
	IUPAC name (S)-1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl)ethyl)isochromane-6-carboxamide;
CAS Number	439081-94-4;
PubChem CID	69904149;
ChemSpider	7977949;
Chemical and physical data
Formula	C25H26FN3O2
Molar mass	419.500 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CC=C1C2=CNC3=C2C=CC(=C3)F)CCC4C5=C(CCO4)C=C(C=C5)C(=O)N;
	InChI InChI=1S/C25H26FN3O2/c26-19-2-4-21-22(15-28-23(21)14-19)16-5-9-29(10-6-16)11-7-24-20-3-1-18(25(27)30)13-17(20)8-12-31-24/h1-5,13-15,24,28H,6-12H2,(H2,27,30)/t24-/m0/s1; Key:AYGLZYIWAZBQDC-DEOSSOPVSA-N;

FormulaC₂₅H₂₆FN₃O₂

LY-456220 is a potent and selective serotonin 5-HT_1D receptor antagonist which has been used in research to study the function of presynaptic 5-HT_1D autoreceptors. LY-456220 lacks significant affinity for the 5-HT_1B, α₁ adrenergic, and dopamine D₂ receptors.^[1]^[2] It is an enantiomer of LY-456219.

Identifiers

IUPAC name (S)-1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl)ethyl)isochromane-6-carboxamide
CAS Number	439081-94-4
PubChem CID	69904149
ChemSpider	7977949
Chemical and physical data
Formula	C₂₅H₂₆FN₃O₂
Molar mass	419.500 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CC=C1C2=CNC3=C2C=CC(=C3)F)CCC4C5=C(CCO4)C=C(C=C5)C(=O)N
InChI InChI=1S/C25H26FN3O2/c26-19-2-4-21-22(15-28-23(21)14-19)16-5-9-29(10-6-16)11-7-24-20-3-1-18(25(27)30)13-17(20)8-12-31-24/h1-5,13-15,24,28H,6-12H2,(H2,27,30)/t24-/m0/s1 Key:AYGLZYIWAZBQDC-DEOSSOPVSA-N

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