Ro60-0213

CAS Number

• 170493-66-0

PubChem CID

• 3045239

ChemSpider

• 2308013

ChEMBL

• ChEMBL2114265

Ro60-0213

Identifiers
IUPAC name (S)-1-(7-methoxyindeno[1,2-b]pyrrol-1(4H)-yl)propan-2-amine
CAS Number	170493-66-0
PubChem CID	3045239
ChemSpider	2308013
ChEMBL	ChEMBL2114265
CompTox Dashboard (EPA)	DTXSID50168866
Chemical and physical data
Formula	C15H18N2O
Molar mass	242.322 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](Cn1ccc2c1-c3cc(ccc3C2)OC)N
InChI InChI=1S/C15H18N2O/c1-10(16)9-17-6-5-12-7-11-3-4-13(18-2)8-14(11)15(12)17/h3-6,8,10H,7,9,16H2,1-2H3/t10-/m0/s1 Key:OTCPUISFVUWAGR-JTQLQIEISA-N
(verify)

Ro60-0213 (Org 35032) is a drug developed by Hoffmann–La Roche, which acts as a potent and selective agonist for the 5-HT_2C serotonin receptor, with more than 100x selectivity over other closely related serotonin receptor subtypes, and little or no affinity at other receptors. It was developed as a potential antidepressant,^[1] but was discontinued from clinical development at an early stage due to toxicity concerns.^[2] However the high selectivity of Ro60-0213 for 5-HT_2C makes it of continued interest for research into serotonin receptors.^[3]