MS-245

MS-245 is a tryptamine derivative used in scientific research. It acts as a selective 5-HT₆ receptor antagonist with a K_i of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT₆ agonist EMDT.^[1] It has been used as a lead compound for further development of tryptamine-derived 5-HT₆ antagonists.^[2][3] In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.^[4][5]

ATC code

• none

CAS Number

• 263384-65-2 ^Y

PubChem CID

• 6918542

ChemSpider

• 5293739

Quick facts Clinical data, ATC code ...

MS-245

Clinical data
ATC code	none
Identifiers
IUPAC name 2-[5-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl]-N,N-dimethylethanamine
CAS Number	263384-65-2 Y
PubChem CID	6918542
ChemSpider	5293739
UNII	L7TKH887Y7
CompTox Dashboard (EPA)	DTXSID501027131
Chemical and physical data
Formula	C19H22N2O3S
Molar mass	358.46 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc2cc1c(CCN(C)C)cn(c1cc2)S(=O)(=O)c3ccccc3
InChI InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3 Key:AIJIQCBYMBZLJD-UHFFFAOYSA-N
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