2022 Cary Challenger

Country	Player	Rank1	Seed
USA	Denis Kudla	96	1
AUS	Jordan Thompson	102	2
USA	Stefan Kozlov	111	3
ARG	Juan Pablo Ficovich	128	4
ARG	Facundo Mena	131	5
AUS	Aleksandar Vukic	132	6
USA	Michael Mmoh	155	7
GER	Dominik Koepfer	161	8

• ¹ Rankings are as of August 29, 2022.^[1]

The following players received wildcards into the singles main draw:

• Martin Damm
• Ryan Seggerman
• Braden Shick

The following players received entry into the singles main draw as alternates:

• Nick Chappell
• Tennys Sandgren

The following players received entry from the qualifying draw:

• Daniil Glinka
• Ryan Harrison
• Garrett Johns
• Cannon Kingsley
• Henry Patten
• Donald Young

• Michael Mmoh def. Dominik Koepfer 7–5, 6–3.

• Nathaniel Lammons / Jackson Withrow def. Treat Huey / John-Patrick Smith 7–5, 2–6, [10–5].