2022 Vilnius Open

Country	Player	Rank1	Seed
CZE	Tomáš Macháč	108	1
LTU	Ričardas Berankis	128	2
ITA	Matteo Arnaldi	154	3
ITA	Gianluca Mager	167	4
SVK	Lukáš Klein	180	5
BIH	Nerman Fatić	199	6
FRA	Laurent Lokoli	204	7
FRA	Antoine Escoffier	211	8

• ¹ Rankings are as of 10 October 2022.^[1]

The following players received wildcards into the singles main draw:^[2]

• Edas Butvilas
• Vilius Gaubas
• Ainius Sabaliauskas

The following player received entry into the singles main draw as a special exempt:

• Matteo Arnaldi

The following player received entry into the singles main draw as an alternate:

• Viktor Durasovic

The following players received entry from the qualifying draw:

• Elliot Benchetrit
• Cem İlkel
• Mark Lajal
• Jules Marie
• David Poljak
• Mats Rosenkranz

The following player received entry as a lucky loser:

• Térence Atmane

• Mattia Bellucci def. Cem İlkel 1–6, 6–3, 7–5.

• Romain Arneodo / Tristan-Samuel Weissborn def. Dan Added / Théo Arribagé 6–4, 5–7, [10–5].