2022 UniCredit Czech Open

Country	Player	Rank1	Seed
ARG	Federico Coria	54	1
CZE	Jiří Veselý	73	2
CZE	Jiří Lehečka	77	3
ESP	Pablo Andújar	98	4
SVK	Norbert Gombos	112	5
SWE	Elias Ymer	127	6
SVK	Andrej Martin	128	7
CZE	Zdeněk Kolář	134	8

• ¹ Rankings are as of 23 May 2022.^[1]

The following players received wildcards into the singles main draw:

• Martin Krumich
• Hamad Međedović
• Lukáš Pokorný

The following player received entry into the singles main draw as a special exempt:

• Lukáš Klein

The following player received entry into the singles main draw as an alternate:

• Vitaliy Sachko

The following players received entry from the qualifying draw:

• Térence Atmane
• Francisco Comesaña
• Martín Cuevas
• Alexander Erler
• Fábián Marozsán
• Lucas Miedler

The following players received entry as lucky losers:

• Benjamin Hassan
• Calvin Hemery
• Louis Wessels

• Vít Kopřiva def. Dalibor Svrčina 6–2, 6–2.

• Yuki Bhambri / Saketh Myneni def. Roman Jebavý / Andrej Martin 6–3, 7–5.