2022 Knoxville Challenger

Country	Player	Rank1	Seed
USA	Michael Mmoh	120	1
USA	Stefan Kozlov	132	2
USA	Christopher Eubanks	135	3
USA	Ben Shelton	156	4
USA	Emilio Nava	174	5
USA	Aleksandar Kovacevic	178	6
FRA	Enzo Couacaud	186	7
CHN	Shang Juncheng	195	8

• ¹ Rankings are as of October 31, 2022.^[1]

The following players received wildcards into the singles main draw:

• Blaise Bicknell
• Gage Brymer
• Martin Damm

The following player received entry into the singles main draw as an alternate:

• Ethan Quinn

The following players received entry from the qualifying draw:

• Alexander Bernard
• Giles Hussey
• Cannon Kingsley
• Strong Kirchheimer
• Tristan McCormick
• Iñaki Montes de la Torre

• Ben Shelton def. Christopher Eubanks 6–3, 1–6, 7–6^(7–4).

• Hunter Reese / Tennys Sandgren def. Martin Damm / Mitchell Krueger 6–7^(4–7), 7–6^(7–3), [10–5].