2022 Internazionali di Tennis Città di Todi

Country	Player	Rank1	Seed
ARG	Pedro Cachin	120	1
ITA	Flavio Cobolli	145	2
FRA	Alexandre Müller	161	3
CRO	Nino Serdarušić	167	4
ARG	Santiago Rodríguez Taverna	176	5
SVK	Filip Horanský	191	6
ARG	Thiago Agustín Tirante	194	7
KAZ	Dmitry Popko	195	8

• ¹ Rankings are as of 27 June 2022.^[1]

The following players received wildcards into the singles main draw:

• Mattia Bellucci
• Matteo Gigante
• Francesco Passaro

The following player received entry into the singles main draw as a special exempt:

• Juan Bautista Torres

The following player received entry into the singles main draw as an alternate:

• Jelle Sels

The following players received entry from the qualifying draw:

• Rémy Bertola
• Andrey Chepelev
• Joris De Loore
• Giovanni Fonio
• Billy Harris
• Francesco Maestrelli

• Pedro Cachin def. Nicolás Kicker 6–4, 6–4.

• Guido Andreozzi / Guillermo Durán def. Romain Arneodo / Jonathan Eysseric 6–1, 2–6, [10–6].