2022 Challenger Rio de Janeiro

Country	Player	Rank1	Seed
ARG	Federico Coria	72	1
PER	Juan Pablo Varillas	107	2
ITA	Marco Cecchinato	114	3
ARG	Camilo Ugo Carabelli	119	4
BRA	Felipe Meligeni Alves	143	5
FRA	Alexandre Müller	145	6
ARG	Juan Manuel Cerúndolo	148	7
GER	Yannick Hanfmann	163	8

• ¹ Rankings are as of 3 October 2022.^[1]

The following players received wildcards into the singles main draw:

• Gustavo Almeida
• João Fonseca
• João Lucas Reis da Silva

The following player received entry into the singles main draw as a special exempt:

• Jan Choinski

The following players received entry into the singles main draw as alternates:

• Genaro Alberto Olivieri
• Juan Bautista Torres
• Gonzalo Villanueva

The following players received entry from the qualifying draw:

• Rémy Bertola
• Giovanni Mpetshi Perricard
• Sumit Nagal
• Mariano Navone
• Jakub Paul
• Juan Pablo Paz

• Marco Cecchinato def. Yannick Hanfmann 4–6, 6–4, 6–3.

• Guido Andreozzi / Guillermo Durán def. Karol Drzewiecki / Jakub Paul 6–3, 6–2.