2022 Challenger de Villa María

Country	Player	Rank1	Seed
PER	Juan Pablo Varillas	100	1
ARG	Camilo Ugo Carabelli	116	2
ARG	Facundo Bagnis	117	3
BRA	Felipe Meligeni Alves	143	4
GER	Yannick Hanfmann	153	5
ARG	Santiago Rodríguez Taverna	158	6
ARG	Renzo Olivo	169	7
ARG	Juan Manuel Cerúndolo	186	8

• ¹ Rankings are as of 12 September 2022.^[2]

The following players received wildcards into the singles main draw:

• Alex Barrena
• Lautaro Midón
• Juan Bautista Otegui

The following player received entry into the singles main draw as an alternate:

• Facundo Juárez

The following players received entry from the qualifying draw:

• Matías Franco Descotte
• Franco Emanuel Egea
• Alejo Lorenzo Lingua Lavallén
• Orlando Luz
• Ignacio Monzón
• Juan Pablo Paz

• Nicolás Kicker def. Mariano Navone 7–5, 6–3.

• Hernán Casanova / Santiago Rodríguez Taverna def. Facundo Juárez / Ignacio Monzón 6–4, 6–3.