2022 Open Harmonie mutuelle

Country	Player	Rank1	Seed
LTU	Ričardas Berankis	87	1
FRA	Quentin Halys	115	2
FRA	Gilles Simon	139	3
	Roman Safiullin	143	4
GBR	Jack Draper	146	5
FRA	Grégoire Barrère	178	6
FRA	Constant Lestienne	205	7
FRA	Antoine Hoang	214	8

• Rankings are as of 21 March 2022.^[1]

The following players received wildcards into the singles main draw:

• Arthur Fils
• Harold Mayot
• Luca Van Assche

The following players received entry into the singles main draw as alternates:

• Malek Jaziri
• Mikael Torpegaard

The following players received entry from the qualifying draw:

• Zizou Bergs
• Alexis Galarneau
• Alastair Gray
• Fábián Marozsán
• Marvin Möller
• Henri Squire

The following players received entry as lucky losers:

• Benjamin Hassan
• Michail Pervolarakis
• Mats Rosenkranz

• Jack Draper def. Zizou Bergs 6–2, 5–7, 6–4.

• Sander Arends / David Pel def. Jonathan Eysseric / Robin Haase 6–3, 6–3.