2022 Città di Como Challenger

Country	Player	Rank1	Seed
ITA	Marco Cecchinato	141	1
ITA	Giulio Zeppieri	146	2
ITA	Francesco Passaro	148	3
SRB	Nikola Milojević	181	4
ITA	Matteo Arnaldi	188	5
ITA	Riccardo Bonadio	189	6
ITA	Stefano Travaglia	190	7
ITA	Andrea Arnaboldi	197	8

• ¹ Rankings are as of 22 August 2022.^[1]

The following players received wildcards into the singles main draw:

• Federico Arnaboldi
• Gianmarco Ferrari
• Matteo Gigante

The following player received entry into the singles main draw as a special exempt:

• Lucas Gerch

The following players received entry into the singles main draw as alternates:

• Oleksii Krutykh
• Lucas Miedler

The following players received entry from the qualifying draw:

• Adrian Andreev
• Marius Copil
• Cezar Crețu
• Nicolas Moreno de Alboran
• Mariano Navone
• Giovanni Oradini

The following player received entry as a lucky loser:

• Kenny de Schepper

• Cedrik-Marcel Stebe def. Francesco Passaro 7–6^(7–2), 6–4.

• Alexander Erler / Lucas Miedler def. Dustin Brown / Julian Lenz 6–1, 7–6^(7–3).