2022 San Marcos Open Aguascalientes

Country	Player	Rank1	Seed
SVK	Andrej Martin	133	1
CHI	Nicolás Jarry	134	2
SUI	Marc-Andrea Hüsler	140	3
USA	Ernesto Escobedo	143	4
GBR	Jay Clarke	170	5
NED	Tim van Rijthoven	184	6
ITA	Federico Gaio	186	7
ARG	Juan Pablo Ficovich	205	8

• ¹ Rankings as of April 11, 2022.^[1]

The following players received wildcards into the singles main draw:

• Diego Balderas
• Rodrigo Pacheco Méndez
• Shang Juncheng

The following player received entry into the singles main draw as a special exempt:

• Antoine Bellier

The following players received entry into the singles main draw as alternates:

• Viktor Durasovic
• Bernard Tomic

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Elmar Ejupovic
• Adrián Menéndez Maceiras
• Shintaro Mochizuki
• Akira Santillan
• Matías Zukas

The following player received entry as a lucky loser:

• Malek Jaziri

• Marc-Andrea Hüsler def. Juan Pablo Ficovich 6–4, 4–6, 6–3.

• Nicolás Barrientos / Miguel Ángel Reyes-Varela def. Gonçalo Oliveira / Divij Sharan 7–5, 6–3.