2022 Challenger de Buenos Aires

Country	Player	Rank1	Seed
ARG	Federico Coria	71	1
GER	Daniel Altmaier	97	2
PER	Juan Pablo Varillas	102	3
ARG	Camilo Ugo Carabelli	119	4
ARG	Facundo Bagnis	120	5
BRA	Felipe Meligeni Alves	144	6
ARG	Santiago Rodríguez Taverna	159	7
GER	Yannick Hanfmann	170	8

• ¹ Rankings are as of 19 September 2022.^[1]

The following players received wildcards into the singles main draw:

• Román Andrés Burruchaga
• Lautaro Midón
• Juan Bautista Otegui

The following player received entry into the singles main draw using a protected ranking:

• Sumit Nagal

The following player received entry into the singles main draw as a special exempt:

• Mariano Navone

The following players received entry into the singles main draw as alternates:

• Facundo Díaz Acosta
• Gonzalo Villanueva

The following players received entry from the qualifying draw:

• Nicolás Álvarez
• Hernán Casanova
• Facundo Juárez
• Wilson Leite
• Ignacio Monzón
• Thiago Seyboth Wild

The following player received entry as a lucky loser:

• Carlos Sánchez Jover

• Juan Manuel Cerúndolo def. Camilo Ugo Carabelli 6–4, 2–6, 7–5.

• Guido Andreozzi / Guillermo Durán def. Román Andrés Burruchaga / Facundo Díaz Acosta 6–0, 7–5.