2022 Open Comunidad de Madrid

Country	Player	Rank1	Seed
ESP	Roberto Carballés Baena	79	1
BRA	Thiago Monteiro	116	2
ESP	Feliciano López	118	3
ESP	Fernando Verdasco	120	4
GER	Mats Moraing	125	5
FRA	Lucas Pouille	135	6
TPE	Tseng Chun-hsin	140	7
SRB	Nikola Milojević	141	8
AUS	Christopher O'Connell	153	9

• ¹ Rankings are as of 4 April 2022.^[1]

The following players received wildcards into the singles main draw:

• Roberto Carballés Baena
• Miguel Damas
• Lucas Pouille

The following player received entry into the singles main draw using a protected ranking:

• Sebastian Ofner

The following players received entry into the singles main draw as alternates:

• Duje Ajduković
• Mathias Bourgue

The following players received entry from the qualifying draw:

• Raúl Brancaccio
• Oleksii Krutykh
• Johan Nikles
• Yshai Oliel
• Oriol Roca Batalla
• Pedro Sousa

The following player received entry as a lucky loser:

• Javier Barranco Cosano

• Pedro Cachin def. Marco Trungelliti 6–3, 6–7^(3–7), 6–3.

• Adam Pavlásek / Igor Zelenay def. Rafael Matos / David Vega Hernández 6–3, 3–6, [10–6].