2022 Internazionali di Tennis Città di Trieste

Country	Player	Rank1	Seed
SVK	Norbert Gombos	112	1
ITA	Franco Agamenone	144	2
ITA	Gianluca Mager	147	3
AUT	Dennis Novak	153	4
ITA	Marco Cecchinato	154	5
SRB	Nikola Milojević	156	6
ARG	Santiago Rodríguez Taverna	161	7
FRA	Alexandre Müller	162	8

• ¹ Rankings are as of 11 July 2022.^[1]

The following players received wildcards into the singles main draw:

• Mattia Bellucci
• Marco Cecchinato
• Matteo Gigante

The following player received entry into the singles main draw as a special exempt:

• Francesco Maestrelli

The following players received entry into the singles main draw as alternates:

• Luciano Darderi
• Nerman Fatić

The following players received entry from the qualifying draw:

• Andrey Chepelev
• Ernests Gulbis
• Lukas Neumayer
• Giovanni Oradini
• Samuel Vincent Ruggeri
• Zhang Zhizhen

• Francesco Passaro def. Zhang Zhizhen 4–6, 6–3, 6–3.

• Diego Hidalgo / Cristian Rodríguez def. Marco Bortolotti / Sergio Martos Gornés 4–6, 6–3, [10–5].