2022 Challenger di Roseto degli Abruzzi

Country	Player	Rank1	Seed
ESP	Carlos Taberner	107	1
ITA	Stefano Travaglia	111	2
ESP	Bernabé Zapata Miralles	118	3
SRB	Nikola Milojević	127	4
SVK	Andrej Martin	128	5
POR	Nuno Borges	165	6
ITA	Flavio Cobolli	178	7
ITA	Gian Marco Moroni	183	8

• ¹ Rankings are as of 28 February 2022.^[1]

The following players received wildcards into the singles main draw:

• Andrea Del Federico
• Francesco Maestrelli
• Francesco Passaro

The following players received entry into the singles main draw as alternates:

• Duje Ajduković
• Andrea Arnaboldi
• Lukáš Rosol

The following players received entry from the qualifying draw:

• Matteo Arnaldi
• Luciano Darderi
• Alexis Gautier
• Carlos Gimeno Valero
• Calvin Hemery
• Nikolás Sánchez Izquierdo

The following player received entry as a lucky loser:

• Elmar Ejupovic

• Carlos Taberner def. Nuno Borges 6–2, 6–3.

• Hugo Nys / Jan Zieliński def. Roman Jebavý / Philipp Oswald 7–6^(7–2), 4–6, [10–3].