2022 Internazionali di Tennis Città di Perugia

Country	Player	Rank1	Seed
ESP	Carlos Taberner	85	1
ESP	Jaume Munar	87	2
ARG	Tomás Martín Etcheverry	88	3
ESP	Roberto Carballés Baena	89	4
BRA	Thiago Monteiro	100	5
COL	Daniel Elahi Galán	106	6
ITA	Gianluca Mager	118	7
PER	Juan Pablo Varillas	121	8

• ¹ Rankings are as of 23 May 2022.^[1]

The following players received wildcards into the singles main draw:

• Matteo Arnaldi
• Matteo Gigante
• Luca Potenza

The following player received entry into the singles main draw as a special exempt:

• Francesco Passaro

The following players received entry into the singles main draw as alternates:

• Borna Ćorić
• Nerman Fatić

The following players received entry from the qualifying draw:

• Elliot Benchetrit
• Luciano Darderi
• Maximilian Marterer
• Giovanni Oradini
• Cristian Rodríguez
• Giorgio Tabacco

The following player received entry as a lucky loser:

• Filippo Baldi

• Jaume Munar def. Tomás Martín Etcheverry 6–3, 4–6, 6–1.

• Sadio Doumbia / Fabien Reboul def. Marco Bortolotti / Sergio Martos Gornés 6–2, 6–4.