2022 Internazionali di Tennis Città di Vicenza

Country	Player	Rank1	Seed
ITA	Gianluca Mager	119	1
ARG	Juan Manuel Cerúndolo	132	2
ITA	Andreas Seppi	137	3
ITA	Flavio Cobolli	153	4
ARG	Renzo Olivo	176	5
KAZ	Dmitry Popko	180	6
ITA	Lorenzo Giustino	205	7
ITA	Salvatore Caruso	207	8

• ¹ Rankings are as of 16 May 2022.^[1]

The following players received wildcards into the singles main draw:

• Salvatore Caruso
• Matteo Gigante
• Francesco Passaro

The following players received entry into the singles main draw as special exempts:

• Matteo Arnaldi
• Francesco Maestrelli

The following players received entry into the singles main draw as alternates:

• Luciano Darderi
• Daniel Dutra da Silva
• Nerman Fatić
• Alexis Galarneau
• Maxime Janvier
• Andrea Pellegrino

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Francisco Comesaña
• Kenny de Schepper
• Giovanni Fonio
• Ernests Gulbis
• Oleg Prihodko

The following player received entry as a lucky loser:

• Yan Bondarevskiy

• Andrea Pellegrino def. Andrea Collarini 6–1, 6–4.

• Francisco Comesaña / Luciano Darderi def. Matteo Gigante / Francesco Passaro 6–3, 7–6^(7–4).