2022 Orlando Open

Country	Player	Rank1	Seed
USA	J. J. Wolf	125	1
ECU	Emilio Gómez	151	2
USA	Christopher Eubanks	156	3
AUS	Jason Kubler	159	4
USA	Michael Mmoh	175	5
TUR	Altuğ Çelikbilek	179	6
USA	Bjorn Fratangelo	185	7
AUS	Rinky Hijikata	233	8

• ¹ Rankings are as of May 23, 2022.^[1]

The following players received wildcards into the singles main draw:

• Brandon Holt
• Aleksandar Kovacevic
• Ben Shelton

The following players received entry into the singles main draw using protected rankings:

• Andrew Harris
• Wu Yibing

The following players received entry into the singles main draw as alternates:

• Malek Jaziri
• Roberto Quiroz
• Denis Yevseyev

The following players received entry from the qualifying draw:

• Adrian Andreev
• Martin Damm
• Gilbert Klier Júnior
• Matija Pecotić
• Michail Pervolarakis
• Keegan Smith

• Wu Yibing def. Jason Kubler 6–7^(5–7), 6–4, 3–1 ret.

• Chung Yun-seong / Michail Pervolarakis def. Malek Jaziri / Kaichi Uchida 6–7^(5–7), 7–6^(7–3), [16–14].