2022 República Dominicana Open

Country	Player	Rank1	Seed
ESP	Roberto Carballés Baena	78	1
ARG	Pedro Cachin	87	2
ARG	Tomás Martín Etcheverry	94	3
COL	Daniel Elahi Galán	97	4
PER	Juan Pablo Varillas	100	5
ARG	Camilo Ugo Carabelli	121	6
ARG	Federico Delbonis	133	7
ARG	Facundo Mena	138	8

• ¹ Rankings were as of 8 August 2022.^[1]

The following players received wildcards into the singles main draw:

• Peter Bertran
• Gonzalo Bueno
• Nick Hardt

The following players received entry into the singles main draw as alternates:

• Gonzalo Lama
• Roberto Quiroz
• Gonzalo Villanueva

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Pedro Boscardin Dias
• Román Andrés Burruchaga
• Facundo Juárez
• Patrick Kypson
• Nicolás Mejía

The following player received entry as a lucky loser:

• Nicolás Álvarez

• Pedro Cachin def. Marco Trungelliti 6–4, 2–6, 6–3.

• Ruben Gonzales / Reese Stalder def. Nicolás Barrientos / Miguel Ángel Reyes-Varela 7–6^(7–5), 6–3.