2022 Mexico City Open

Country	Player	Rank1	Seed
ARG	Facundo Bagnis	104	1
ARG	Tomás Martín Etcheverry	108	2
USA	Stefan Kozlov	120	3
SVK	Andrej Martin	128	4
ARG	Juan Ignacio Londero	130	5
USA	Ernesto Escobedo	133	6
CHI	Nicolás Jarry	142	7
GBR	Jay Clarke	168	8

• ¹ Rankings are as of 21 March 2022.^[1]

The following players received wildcards into the singles main draw:

• Luis Carlos Álvarez
• Alex Hernández
• Nicolás Jarry

The following players received entry into the singles main draw as alternates:

• Viktor Durasovic
• Denis Istomin
• Peđa Krstin
• Bernard Tomic

The following players received entry from the qualifying draw:

• Mateus Alves
• Nicolás Barrientos
• Nick Chappell
• Elmar Ejupovic
• Gilbert Klier Júnior
• Keegan Smith

• Marc-Andrea Hüsler def. Tomás Martín Etcheverry 6–4, 6–2.

• Nicolás Jarry / Matheus Pucinelli de Almeida def. Jonathan Eysseric / Artem Sitak 6–2, 6–3.