2022 San Luis Open Challenger

Country	Player	Rank1	Seed
SVK	Andrej Martin	129	1
CHI	Nicolás Jarry	139	2
USA	Ernesto Escobedo	142	3
ARG	Facundo Mena	159	4
GBR	Jay Clarke	166	5
SUI	Marc-Andrea Hüsler	176	6
ITA	Federico Gaio	186	7
ARG	Renzo Olivo	203	8

• ¹ Rankings are as of 4 April 2022.^[1]

The following players received wildcards into the singles main draw:

• Alex Hernández
• Shintaro Mochizuki
• Rodrigo Pacheco Méndez

The following players received entry into the singles main draw as alternates:

• Viktor Durasovic
• Peđa Krstin

The following players received entry from the qualifying draw:

• Antoine Bellier
• Hady Habib
• Gilbert Klier Júnior
• Roberto Quiroz
• Shang Juncheng
• Matías Zukas

• Antoine Bellier def. Renzo Olivo 6–7^(2–7), 6–4, 7–5.

• Nicolás Barrientos / Miguel Ángel Reyes-Varela def. Luis David Martínez / Felipe Meligeni Alves 7–6^(13–11), 6–2.