2022 São Léo Open

Country	Player	Rank1	Seed
ARG	Facundo Bagnis	103	1
PER	Juan Pablo Varillas	116	2
ITA	Franco Agamenone	154	3
BRA	Felipe Meligeni Alves	164	4
ARG	Renzo Olivo	186	5
ARG	Facundo Díaz Acosta	188	6
BRA	Matheus Pucinelli de Almeida	199	7
POR	Gastão Elias	214	8

• ¹ Rankings are as of 7 November 2022.^[2]

The following players received wildcards into the singles main draw:

• João Fonseca
• Gustavo Heide
• Matheus Pucinelli de Almeida

The following players received entry into the singles main draw as alternates:

• João Lucas Reis da Silva
• Thiago Seyboth Wild

The following players received entry from the qualifying draw:

• Mateus Alves
• Leo Borg
• Max Houkes
• Wilson Leite
• Juan Pablo Paz
• Damien Wenger

The following player received entry as a lucky loser:

• Eduardo Ribeiro

• Juan Pablo Varillas def. Facundo Bagnis 7–6^(7–5), 4–6, 6–4.

• Guido Andreozzi / Guillermo Durán def. Felipe Meligeni Alves / João Lucas Reis da Silva 5–1 ret.