2022 Challenger de Tigre

Country	Player	Rank1	Seed
ARG	Guido Andreozzi	271	1
ARG	Santiago Rodríguez Taverna	302	2
ARG	Genaro Alberto Olivieri	313	3
CHI	Gonzalo Lama	322	4
ARG	Hernán Casanova	325	5
ESP	Carlos Gimeno Valero	329	6
ARG	Facundo Díaz Acosta	338	7
ITA	Luciano Darderi	341	8

• ¹ Rankings are as of 27 December 2021.^[1]

The following players received wildcards into the singles main draw:

• Valerio Aboian
• Juan Manuel La Serna
• Lautaro Midón

The following player received entry into the singles main draw as an alternate:

• Mariano Kestelboim

The following players received entry from the qualifying draw:

• Leonardo Aboian
• Alec Deckers
• Murkel Dellien
• Federico Agustín Gómez
• Tomás Lipovšek Puches
• José Pereira

• Santiago Rodríguez Taverna def. Facundo Díaz Acosta 6–4, 6–2.

• Conner Huertas del Pino / Mats Rosenkranz def. Matías Franco Descotte / Facundo Díaz Acosta 5–6 retired.