2022 Santa Cruz Challenger

Country	Player	Rank1	Seed
BOL	Hugo Dellien	114	1
SVK	Andrej Martin	116	2
ARG	Francisco Cerúndolo	127	3
ARG	Tomás Martín Etcheverry	131	4
CZE	Zdeněk Kolář	143	5
ESP	Fernando Verdasco	170	6
ARG	Facundo Mena	209	7
ARG	Camilo Ugo Carabelli	215	8

• ¹ Rankings are as of 17 January 2022.^[2]

The following players received wildcards into the singles main draw:

• Boris Arias
• Murkel Dellien
• Federico Zeballos

The following player received entry into the singles main draw as an alternate:

• Nicolás Álvarez

The following players received entry from the qualifying draw:

• Pedro Cachin
• Matías Franco Descotte
• Diego Hidalgo
• Juan Carlos Prado Ángelo
• Cristian Rodríguez
• Gonzalo Villanueva

The following player received entry as a lucky loser:

• Michel Vernier

• Francisco Cerúndolo def. Camilo Ugo Carabelli 6–4, 6–3.

• Diego Hidalgo / Cristian Rodríguez def. Andrej Martin / Tristan-Samuel Weissborn 4–6, 6–3, [10–8].