4C-T-2

4C-T-2
Clinical data
Other names	4-Ethylthio-2,5-dimethoxy-α-ethylphenethylamine
ATC code	None;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 1-[(2,5-dimethoxy-4-ethylthio)phenyl]butan-2-amine;
CAS Number	850007-13-5 ; 849919-79-5 (hydrochloride);
PubChem CID	11197523;
ChemSpider	9372592 ;
UNII	AY9HDQ4A2H;
ChEMBL	ChEMBL372719 ;
CompTox Dashboard (EPA)	DTXSID001029306 ;
Chemical and physical data
Formula	C14H23NO2S
Molar mass	269.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(CC(CC)N)C=C(OC)C(SCC)=C1;
	InChI InChI=1S/C14H23NO2S/c1-5-11(15)7-10-8-13(17-4)14(18-6-2)9-12(10)16-3/h8-9,11H,5-7,15H2,1-4H3 ; Key:KLAWPCIXPDTGCZ-UHFFFAOYSA-N ;
	(verify)

Other names4-Ethylthio-2,5-dimethoxy-α-ethylphenethylamine

4C-T-2, also known as 2,5-dimethoxy-4-ethylthio-α-ethylphenethylamine, is a synthetic drug of the phenethylamine, phenylisobutylamine, and 4C families.^[1]^[2]^[3] It is the α-ethylated analogue of 2C-T-2.^[1]^[2]^[3]

Target	Affinity (K_i, nM)
5-HT_1A	5,339
5-HT_1B	>10,000
5-HT_1D	>10,000
5-HT_1E	9,879
5-HT_1F	ND
5-HT_2A	274 (K_i) 13.1–53 (EC₅₀Tooltip half-maximal effective concentration) 78% (E_maxTooltip maximal efficacy)
5-HT_2B	58.1 (K_i) 630 (EC₅₀) ND (E_max)
5-HT_2C	469 (K_i) 7.3–13.2 (EC₅₀) 86–121% (E_max)
5-HT₃	>10,000
5-HT₄	ND
5-HT_5A	1,587
5-HT₆	>10,000
5-HT₇	3,829
α_1A, α_1B	>10,000
α_1D	ND
α_2A–α_2C	>10,000
β₁	>10,000
β₂	124.9
β₃	ND
D₁, D₂	>10,000
D₃	1,273
D₄, D₅	>10,000
H₁–H₄	>10,000
M₁–M₅	>10,000
I₁	946.5
σ₁	514.6
σ₂	>10,000
TAAR1Tooltip Trace amine-associated receptor 1	ND
SERTTooltip Serotonin transporter	>10,000 (K_i)
NETTooltip Norepinephrine transporter	>10,000 (K_i)
DATTooltip Dopamine transporter	>10,000 (K_i)
MAO-ATooltip Monoamine oxidase A	11,800 (IC₅₀Tooltip half-maximal inhibitory concentration)
MAO-BTooltip Monoamine oxidase B	>100,000 (IC₅₀)
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: ^[4]^[5]^[2]^[3]^[6]

Pharmacodynamics