Tiflucarbine

Tiflucarbine
Clinical data
Other names	BAY-P 4495; TVX P 4495
Drug class	Serotonin receptor agonist
ATC code	None;
Identifiers
	IUPAC name 9-Ethyl-4-fluoro-1-methyl-7,8,9,10-tetrahydro-6H-pyrido[4,3-b]thieno[3,2-e]indole;
CAS Number	89875-86-5;
PubChem CID	65677;
ChemSpider	59106;
UNII	M2108NUY0C;
ChEMBL	ChEMBL2104715;
CompTox Dashboard (EPA)	DTXSID90237924 ;
Chemical and physical data
Formula	C16H17FN2S
Molar mass	288.38 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN1CCC2=C(C1)C3=C4C(=CSC4=C(C=C3N2)F)C;
	InChI InChI=1S/C16H17FN2S/c1-3-19-5-4-12-10(7-19)15-13(18-12)6-11(17)16-14(15)9(2)8-20-16/h6,8,18H,3-5,7H2,1-2H3; Key:BNKIWXODDDABSJ-UHFFFAOYSA-N;

Other namesBAY-P 4495; TVX P 4495

Tiflucarbine (BAY-P 4495 or TVX P 4495) is an experimental drug which acts as an agonist of the 5-HT₁ and 5-HT₂ serotonin receptor families, and also acts as a calmodulin inhibitor. It has antidepressant effects in animal studies.^[1]^[2]^[3]^[4] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.^[2]^[5] In addition, it partially substituted for DOM and 8-OH-DPAT in rodent drug discrimination tests, with further generalization but concomitant substantial behavioral disruption in 5-MeO-DMT-trained rodents.^[2] Tiflucarbine is similar in structure to but distinct from β-carbolines, instead being a γ-carboline.

References