HLF (gene)

From Wikipedia, the free encyclopedia

AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
End55,325,187 bp[1]
HLF
Identifiers
AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDsOMIM: 142385; MGI: 96108; HomoloGene: 31074; GeneCards: HLF; OMA:HLF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

Location (UCSC)Chr 17: 55.26 – 55.33 MbChr 11: 90.23 – 90.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

Further reading

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